AMG-548 dihydrochloride Size:2mg solid ROC-325 induces hallmark features of

ROC-325 induces hallmark features of autophagy inhibition and antagonizes autophagic flux

CAS Number: 53678-77-6

It is also orally bioavailable

31)/t18-/m1/s1

AMG-548 dihydrochloride Size:2mg solid ROC-325 induces hallmark features ofAMG 548 dihydrochloride, an orally active and selective p38 inhibitor (Ki=0. 5 nM), shows slightly selective over p38 (Ki=36 nM) and >1000 fold selective against p38 and p38. AMG 548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNF (IC50=3 nM). AMG 548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms and . Product information Molecular Weight: 534. 48 Formula: