I run Exquisite Blood and Sanguine Bond in my Edgar Markov deck
Merlin, Shapeshifter, the first of the two main cards in this deck, has an Ink cost of 4, a low Strength of 1 and an excellent Willpower of 5
Time Walk was an iconic and expensive card at the time it was banned, and removing it from the card pool was intended to combat the notion that Commander is a prohibitively expensive and inaccessible format
It sounds simple, but because there are few restrictions on who, or what, you can damage, it allows you to target cards that are Evasive, cards that aren't exerted, and, really, any card with willpower