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Aztreonam is a monobactam antibiotic used primarily to treat infections caused by gram-negative bacteria
JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0
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GNF-6231 0636457-O-C3-COOH Aztreonam is a monobactam antibioticGNF 6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. 1) GNF 6231 shows IC50s of greater than 10 M on all CYP isoforms tested2) GNF 6231 have favorable potency and a PK profile across preclinical species upon oral administration. 3) The reference for orally in MMTV Wnt1 tumor bearing mice is dosed at 3 mg kg. 4) GNF 6231 showed very robust dose related antitumor efficacy. Product information CAS
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