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The key thing here is that Insolent Neonate allows a player to discard before drawing, which means that you can discard a card with dredge and then, instead of drawing the card, immediately start dredging

You can also flicker or reanimate it if youre looking to get extra value

Mind Twist Targeted discard takes a huge hit in Commander compared to Constructed formats, since it typically only interacts with one opponent and doesnt affect the board

Giving all your dragons indestructible means you can swing and block without fear, and the bonus of stacking +1/+1 counters every upkeep quickly snowballs, all on top of a potential alternate win condition