Ispinesib (SB-715992) st N-oxide Nateglinide inhibits typical recordings of

Nateglinide inhibits typical recordings of dinitrophenol-induced KATP currents in a concentration-dependent manner

GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators

PubMed PMID: 26259519

or inflammation

Ispinesib (SB-715992) st N-oxide Nateglinide inhibits typical recordings ofIspinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be