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EX-527 was used at 1-10 µM in vitro and in cellular assays
3-30 mg/kg) reduces mortality against HSV-1
“LFU835-expanded Umbilical Cord Blood Hematopoietic Stem Cells in Patients With Hematological Malignancies”
Eur J Nutr
FG-4592 (Roxadustat) - HIF Prolyl-Hydroxylases Inhibitor. CAS# 808118-40-3 Catalog No.:M60263-10S EX-527 was used at 1-10FG 4592 (Roxadustat), CAS No. 808118 40 3, is a potent, selective and bioavailable inhibitor of hypoxia inducible factor prolyl hydroxylase. It is an analog of 2 oxoglutarate (2 OG) to inhibit HIF PH and prevent HIF turnover. While little has been published regarding the actions of this compound, similar HIF PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.