![PF-03715455 524evizinone Smiles: C[C@]12[C@H]3[C@H](C(O)=O)[C@@]45C[C@@](O)(CC[C@H]4[C@@]3(C=C[C@@H]1O)OC2=O)C(=C)C5](https://cdn.shopify.com/s/files/1/0389/1897/9723/files/1688613935459.png?v=1688613958)
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Smiles: C[C@]12[C@H]3[C@H](C(O)=O)[C@@]45C[C@@](O)(CC[C@H]4[C@@]3(C=C[C@@H]1O)OC2=O)C(=C)C5
Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members
suggesting that the clathrin TD regulates coated pit dynamics
98 μM in surface plasmon resonance (SPR) assay
PF-03715455 524evizinone Smiles: C[C@]12[C@H]3[C@H](C(O)=O)[C@@]45C[C@@](O)(CC[C@H]4[C@@]3(C=C[C@@H]1O)OC2=O)C(=C)C5PF 03715455 is a potent inhaled p38 MAPK inhibitor. PF 03715455 shows some selectivity for p38 over p38 with respective IC50 values of 0. 88 and 23 nM. PF 03715455 potently inhibits LPS induced TNF production in human whole blood (IC50=1. 7 nM). PF 03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease). Product information CAS Number: 1056164 52 3 Molecular Weight: 700. 27 Formula: C35H34ClN7O3S2 Chemical Name: 3 [3
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