Masitinib Size:2mg solid resulting in the down-regulation of

resulting in the down-regulation of phosphorylated-FLT3/STAT5

9 μM for UNBS3157 and UNBS5162

PubMed PMID: 16515549

CAS Number: 1792999-26-8

Masitinib Size:2mg solid resulting in the down-regulation ofMasitinib, also known as AB1010, is an orally bioavailable and multi targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild type and mutated forms of the stem cell factor receptor (c Kit; SCFR); platelet derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor