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110(9):3281-90
GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1
is a novel naphthalimide that binds to DNA by intercalation and suppresses CXCL chemokine elaboration
000-fold selectivity against other HMTs
GDC-0449 (Vismodegib) - Hedgehog Antagonist. CAS# 879085-55-9 094 110(9):3281-90Vismodegib (GDC 0449), CAS No. 879085 55 9, is a potent and specific hedgehog pathway inhibitor with an IC50 of 3 nM. It has been approved by FDA to treat BCC, and also in multiple clinical trials to treat advanced solid tumors. It blocks the activities of the Hedgehog ligand cell surface receptors PTCH and or SMO and suppressing Hedgehog signaling. It prevents multiple ATP binding cassette (ABC) transporters. GDC 0449 also exhibited efficacy in