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Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9
1401028-25-8 (free base
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator that induces apoptosis in NB4 cells via negatively regulating intracellular NO and Zn2+ signaling
is more convenient to incorporate the nitro group after deprotection lithium aluminum hydride
IM-250 isantherin A Small-molecule anticancer compounds selectively targetIM 250 not only reduces the duration of disease symptoms or time to healing but also prevents recurrent disease in guinea pigs. Treatment of recurrent infections reduces the frequency of recurrences and viral shedding, and, unlike nucleosidic drugs, IM 250 remains effective for a time after cessation of treatment. Hence, IM 250 has advantages over standard of care therapies and represents a promising therapeutic for chronic HSV infection, including
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