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orally bioavailable and well tolerated pan-Pim kinase inhibitor
COH-SR4 shows potent anti-proliferative activities against leukemia
from a weak inhibition of cell proliferation in human erythroleukaemia cell line (K562) to a strong inhibition in human neuroblastoma cells (SK-N-AS)
Barrientos JC
Baccatin III 19346 orally bioavailable and well toleratedBaccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs. Product information CAS Number: 27548 93 2 Molecular Weight: 586. 63 Formula: C31H38O11 Chemical Name: (1S,2S,3R,4S,7R,9S,10S,12R,15S) 4,12 bis(acetyloxy) 1,9,15 trihydroxy 10,14,17,17 tetramethyl 11 oxo 6 oxatetracyclo[11. 3. 1. 0,. 0,]heptadec 13 en 2 yl