HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Amatangelo MD

347174-05-4

and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism

HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S Tyrosine kinase inhibitorsHIF C2, CAS No. 1422955 31 4, is a potent and selective allosteric inhibitor of hypoxia inducible factor 2 (HIF 2). It binds within the internal cavity of HIF 2 PAS B (Kd of 81 nM) and disrupts heterodimerization of the full length HIF 2 transcription factor. HIF C2 functions effectively as a HIF 2 inhibitor in living cells, disrupting HIF 2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF C2 is selective for the HIF 2