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GW-257406X
3-b]pyridin-5-yl)-1H-pyrazolo[3
Bromberg J
InChiKey: XKLMZUWKNUAPSZ-UHFFFAOYSA-N
L-685458 - CAS# 292632-98-5 se sulfate GW-257406XL 685458 is a potent transition state analog (TSA) secretase inhibitor (GSI). L 685458 inhibits amyloid protein precursor secretase activity with IC50 of 17 nM, shows greater than 50 100 fold selectivity over other aspartyl proteases tested. L685458 inhibits secretase mediated cleavage of APP C99 and Notch 100 with IC50s of 301. 3 nM and 351. 3 nM, respectively. L 685458 can be used for the research of alzheimers disease (AD) and cancers. Product
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