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A-887826 effectively suppresses evoked action potential firing when DRG neurons are held at depolarized potentials and reversibly suppresses spontaneous firing in small diameter DRG neurons from complete Freund's adjuvant inflamed rats
low protein binding (88
C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8
is a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics
Compound 56 Catalog No.:M22023-C A-887826 effectively suppresses evoked actionCompound 56, 4 [(3 Bromophenyl)amino] 6,7 diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (EGFR) showing an IC50 of 0. 006 nM. It competitively binds at the adenosine triphosphate (ATP) site of EGFR. Compound 56 is capable of inhibiting the phosphorylation of EGF dependent EGFR, suppressing the proliferation and clonogenicity of a wide panel of EGFR overexpressing human cancer