A-385358 iethyl ester 33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H

33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H

daily) treatment in mice leads to a significant dose-dependent inhibition of tumor growth

42(10):1684-6

KU59403 with a single daily dose of 12

A-385358 iethyl ester 33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10HA 385358 is a selective inhibitor of Bcl XL with Kis of 0. 80 and 67 nM for Bcl XL and Bcl 2, respectively. Product information CAS Number: 406228 55 5 Molecular Weight: 639. 83 Formula: C32H41N5O5S2 Chemical Name: N (4 {[(2R) 4 (dimethylamino) 1 (phenylsulfanyl)butan 2 yl]amino} 3 nitrobenzenesulfonyl) 4 (4,4 dimethylpiperidin 1 yl)benzamide Smiles: CN(C)CC[C@H](CSC1C=CC=CC=1)NC1=CC=C(C=C1[N+]([O ])=O)S(=O)(=O)NC(=O)C1C=CC(=CC=1)N1CCC(C)(C)CC1