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PubMed Central PMCID: PMC4125721
3-dihydro-1H-benzo[d]imidazol-5-yl)-3
Epub 2013 Aug 10
demonstrated synergistic cytotoxicity against myeloma cells
(S)-Willardiine Catalog No.:M8448-2 PubMed Central PMCID: PMC4125721(S) Willardiine is a potent agonist of AMPA kainate receptors with EC50 of 44. 8 uM. IC50 value: 44. 8 uM(EC50) Target: AMPA kainate receptor agonistin vitro: The (S) but not (R) isomers of willardiine and 5 bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses . At a concentration of 1. 8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% . in vivo: In newborn mice (P5,
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