PHT-7.3 l-PEG4-Val-Cit-PAB-OH ClH/c1-45(2)39-35-37(60-33-31-58-29-27-56-24-23-54-20-19-52-7)13-15-41(39)50(5)43(45)11-9-8-10-12-44-46(3

ClH/c1-45(2)39-35-37(60-33-31-58-29-27-56-24-23-54-20-19-52-7)13-15-41(39)50(5)43(45)11-9-8-10-12-44-46(3

aureus in vivo (20/20 mice survived in an i

InChiKey: BJEPYKJPYRNKOW-REOHCLBHSA-N

then dephosphorylates the amino termini of NFAT proteins resulting a conformational change

PHT-7.3 l-PEG4-Val-Cit-PAB-OH ClH/c1-45(2)39-35-37(60-33-31-58-29-27-56-24-23-54-20-19-52-7)13-15-41(39)50(5)43(45)11-9-8-10-12-44-46(3PHT 7. 3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4. 7 M). PHT 7. 3 inhibits mut KRas, but not wild type KRas cancer cell and tumor growth and signaling. PHT 7. 3 has antitumor activity. Product information CAS Number: 1614225 93 2 Molecular Weight: 433. 52 Formula: C24H23N3O3S Chemical Name: 4 [(1,3 dioxan 2 yl)methyl] 2 {[4 (4 methylphenyl) 1,3 thiazol 2 yl]methyl} 1,2