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PubMed PMID: 17366323
The IC50 values at 24 hour
both of which harbor constitutively active Stat3
leading to their malformation and Hedgehog signaling blockade
Batimastat - CAS# 130370-60-4 (SHR-3162) PubMed PMID: 17366323Batimastat, CAS No. 130370 60 4, is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Matrix metalloproteinases (MMPs) are thought to play a significant role in tumor invasion and metastasis as well as angiogenesis. Batimastat, also known as BB 94, acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs. Product information CAS