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2016 Jan 28
AG-120 was dosed orally to mice bearing IDH1 mutant tumors at 150 mg/Kg once per day
small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity
and EGFR with IC50 of >14 μM
Topiramate 000067 2016 Jan 28Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. The drug had previously been used off label for this purpose. Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox Gastaut
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