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R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested
and 10 µM)
It also inhibits the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2C19 (IC50s = 13 and 8 μM
339(1):228-37
BLU-9931 - CAS# 1538604-68-0 255 R112 also blocked leukotriene C4BLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor
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