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Molecular Weight: 584
Chemical Name: N-(4-(trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide
1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg)
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Z-VDVAD-FMK 21843 Molecular Weight: 584Jurkat T lymphocytes treated with an irreversible caspase 2 inhibitor, benzyloxycarbonyl Val Asp(OMe) Val Ala Asp(OMe) fluoromethyl ketone (Z VDVAD FMK), or stably transfected with pro caspase 2 antisense (Casp 2 AS) are refractory to cytochrome c release stimulated by etoposide1. When etoposide induced activation of pro caspase 2 is subverted by Z VDVAD FMK or stable transfection of pro caspase 2 antisense, cytochrome c release and other