SR9011 - REV-ERB Agonist. CAS# 1379686-29-9 Catalog No.:M66049-2S 01 mg/kg) and the higher

01 mg/kg) and the higher (2 mg/kg) doses are ineffective

It is used in a chemical cocktail of seven small molecules to directly convert human fibroblasts into neuronal cells bypassing a neural progenitor stage

Pre-treatment of AML cells with IPI-145 inhibits both adhesion and migration of AML blasts to bone marrow stromal cells

CAS Number: 215303-72-3

SR9011 - REV-ERB Agonist. CAS# 1379686-29-9 Catalog No.:M66049-2S 01 mg/kg) and the higherSR9011, CAS No. 1379686 29 9, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~790 nM and REV ERB with EC50 ~560 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock