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plays an important role in cancer progression as it affects the stability of p53
1-6H3/t17-/m1/s1
McCullough PA
[Epub ahead of print] PubMed PMID: 20502937
IWR-1 - CAS# 1127442-82-3 60189 plays an important role inIWR 1, also known as IWR 1 endo, CAS No. 1127442 82 3, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine binding site. IWR 1 inhibits epithelial mesenchymal transition of colorectal cancer cells through suppressing Wnt catenin signaling as well as survivin expression. IWR 1 inhibits cell proliferation and EMT even in the presence of TNF induced cancer cell stimulation. IWR 1 also significantly
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