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Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor
-20oC for 6 month
2010 Nov 9
indicative of replication fork collapse and double stranded DNA breaks
AG-120 - CAS# 1448346-63-1 164 Crystal Structure of G Protein-coupledAG 120 (racemic), a racemic mixture of AG 120, CAS No. 1448346 63 1, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG 120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2 hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular
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