M3814 (nedisertib) 8445 2 and 5 μM Neferine

2 and 5 μM Neferine are used in the remaining experiments

Formula: C19H21Br2N3O

trade name Victrelis)

for use as a precursor to photoswitchable Degraders (PHOTACs)

M3814 (nedisertib) 8445 2 and 5 μM NeferineNedisertib (M3814) is a potent and selective inhibitor of DNA dependent Protein Kinase (DNA PK), with an IC50 of <3 nM. Nedisertib (Compound 136) is a potent and selective inhibitor of DNA PK, with an IC50 of <3 nM for DNA PK and <0. 5 for cellular pDNA PK. In combination with IR, Nedisertib shows efficacy in all of the 6 mouse models of human cancer. In all models, a dose of 2 Gy administered daily for 1 week in combination with Nedisertib induces