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TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer
PubMed PMID: 25712356
Stephen Willingham
and both analgesic and antiinflammatory effects in animal studies comparable to naproxen
Salinosporamide A (NPI-0052) Catalog No.:M7476-10 TOPK (T-LAK cell-originated protein kinase)Salinosporamide A (NPI 0052, ML858, Marizomib, MRZ) is a novel marine derived proteasome inhibitor which inhibits CT L 5, C L 1, and T L 2 proteasome activities in human erythrocyte derived 20S proteasomes with IC50 of 3. 5 nM, 430 nM, 28 nM. Product information CAS Number: 437742 34 2 Molecular Weight: 313. 78 Formula: C15H20ClNO4 Synonym: ML858 Marizomib MRZ Chemical Name: (1R,4R,5S) 4 (2 chloroethyl) 1 ((S) ((S) cyclohex 2 en 1 yl)(hydroxy)methyl)
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