U-73343 - CAS# 142878-12-4 Catalog No.:M17881-C AG-490 (50 μM) can induce

AG-490 (50 μM) can induce apoptosis of imatinib-resistant BaF3 cells expressing T315I and E255K mutants of Bcr-Abl

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability

and these effects are blocked by ER antagonists

U-73343 - CAS# 142878-12-4 Catalog No.:M17881-C AG-490 (50 μM) can induceU 73343, works as a protonophore, is an inactive analog of U 73122 and can be used as a negative control. U 73343 dose dependently inhibits acid secretion irrespective of the stimulant. U 73122 is a phospholipase C (PLC) and 5 LO (5 lipoxygenase) inhibitor with an IC50 of 1 2. 1 M for PLC. Product information CAS Number: 142878 12 4 Molecular Weight: 466. 66 Formula: C29H42N2O3 Chemical Name: 1 (6 {[(1S,3aS,3bR,9bS,11aS) 7 methoxy 11a methyl