Pexidartinib G4-Amine 1021/acsmedchemlett

1021/acsmedchemlett

with an IC(50) <0

44-tris((1H-imidazol-4-yl)methyl)-59-amino-17-(3-amino-3-oxopropyl)-14-(4-aminobutyl)-2

8-trihydroxyanthraquinone

Pexidartinib G4-Amine 1021/acsmedchemlettPexidartinib (PLX 3397) is a potent, orally active, selective, and ATP competitive colony stimulating factor 1 receptor (CSF1R or M CSFR) and c Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX 3397) exhibits 10 to 100 fold selectivity for c Kit and CSF1R over other related kinases. Pexidartinib (PLX 3397) induces cell apoptosis and has anti tumor activity. Product information CAS Number: 1029044 16 3 Molecular Weight: 417. 81