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RET V804M-IN-1 (compound 5) exhibits 3
It acts as an antagonist of the μ-opioid receptor (MOR) and as an agonist of the κ-opioid receptor (KOR)
VU0467485 (AZ13713945) displays moderate to high CNS penetration
EPZ-6438 inhibits EZH2 in a manner competitive with the substrate S-adenosylmethionine (SAM)
Xylopine Catalog No.:M17766-C RET V804M-IN-1 (compound 5) exhibitsXylopine is an aporphine alkaloid with cytotoxic activity on cancer cells. Xylopine induces oxidative stress, causes G2 M cell cycle arrest and apoptosis in cancer cells. Product information CAS Number: 517 71 5 Molecular Weight: 295. 33 Formula: C18H17NO3 Chemical Name: (12R) 16 methoxy 3, 5 dioxa 11 azapentacyclo[10. 7. 1. 02, 6. 08, 20. 014, 19]icosa 1(20), 2(6), 7, 14(19), 15, 17 hexaene Smiles: COC1=CC2C[C@H]3NCCC4=CC5OCOC=5C(=C43)C=2C=C1
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