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HS-173 treatment reduces cell viability in two hepatic stellate cell lines in a dose and time dependent manner
and augmented animal survival
decreases Bcl-xL expression and triggers apoptosis of transformed Ba/F3 cells
Schrump DS
PROTAC Bcl2 degrader-1 Catalog No.:M7983-2 HS-173 treatment reduces cell viabilityPROTAC Bcl2 degrader 1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl 2 (IC50, 4. 94 M; DC50, 3. 0 M) and Mcl 1 (IC50, 11. 81 M) by introducing the E3 ligase cereblon (CRBN) binding ligand pomalidomide to Mcl 1 Bcl 2 dual inhibitor Nap 1. Product information CAS Number: 2378801 85 3 Molecular Weight: 941. 84 Formula: C45H45BrN6O10S Chemical Name: N' (2 {8 [(4 bromophenyl)sulfanyl] 2, 4 dioxo 3 azatricyclo[7.
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