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Nature Chem Biol
An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression
1996 Jan 5
especially those derived from secretory lineages that have increased secretory load and increased basal levels of ER stress (including myelomas
CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 0187 Nature Chem BiolCB 5083, CAS No. 1542705 92 9, is a novel first in class, potent orally bio available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti tumor activity in solid and hematological models . CB 5083 causes rapid and sustained accumulation of poly ubiquitin in tumor xenografts after a single administration. CB 5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB 5083 appears to
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