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BGJ-398 shows a rapid distribution from the vascular compartment into the peripheral tissues
InChi: InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6
27(12):2992-3000
The proinflammatory marker MHC-II expressed on myeloid cells but not neurons also appears to be less abundant in confocal sections in G2019S+ rats treated with PF-06447475
GS-444217 LSB BGJ-398 shows a rapid distributionGS 444217 (ASK1 IN 1) is a potent, selective, orally available and ATP competitive inhibitor of ASK1 (apoptosis signal regulating kinase 1) with IC50 of 2. 87 nM. Product information CAS Number: 1262041 49 5 Molecular Weight: 411. 46 Formula: C23H21N7O Synonym: ASK1 IN 1 Chemical Name: 4 (4 Cyclopropyl 1H imidazol 1 yl) N (3 (4 cyclopropyl 4H 1,2,4 triazol 3 yl)phenyl)picolinamide Smiles: O=C(NC1=CC(=CC=C1)C1=NN=CN1C1CC1)C1=CC(=CC=N1)N1C=C(N=C1)C1CC1
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