PND-1186 Catalog No.:M9572-2 also known as Gefitinib-based PROTAC

also known as Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11

Isoprenaline (5 nM and 10 mM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM)

InChiKey: QXTWSUQCXCWEHF-JXMROGBWSA-N

Probes1_000047

PND-1186 Catalog No.:M9572-2 also known as Gefitinib-based PROTACPND 1186, also known as SR 2156 and VS 4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1. 5 nM in vitro. PND 1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1. 0 M PND 1186 (>5 fold above IC50) had limited effects on cell proliferation. However, under non adherent conditions as spheroids and as colonies in soft agar, 0. 1 M PND 1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase 3