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SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor
NatChem Biol
InChi: InChI=1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10
after 60 mins) exhibits a LD50 of 57
TS 155-2 Catalog No.:M22541-C SIRT5 inhibitor 1 is aTS 155 2, is a macrocyclic lactone related to hygrolidin, is produced by a different Streptomyces species found in oil. It blocks thrombin evoked calcium (Ca2+) entry into cells. TS155 2 exerts hypotensive, anti platelet, anti ischaemic and anti inflammatory activity showed on the original patent, however, no literature investigation of TS155 2 is available. A rapid increase in cytosolic Ca2+ is related to the signal transduction events following the
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