Tirapazamine 0577 CCOC(=O)[C@H](CCC1C=CC=CC=1)N[C@H]1CCCN2CCC[C@@H](C(O)=O)N2C1=O

CCOC(=O)[C@H](CCC1C=CC=CC=1)N[C@H]1CCCN2CCC[C@@H](C(O)=O)N2C1=O

Non-ATP-competitive

Goodwin NC

Sneeringer CJ

Tirapazamine 0577 CCOC(=O)[C@H](CCC1C=CC=CC=1)N[C@H]1CCCN2CCC[C@@H](C(O)=O)N2C1=OTrapazamine, also known as SR 4233,DNA damaging drug potentially for the treatment of cervical carcinoma, head and neck cancer. Tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by radiotherapy and most anticancer drugs. Thus the combination of tirapazamine with conventional anticancer treatments is particularly effective. Product information CAS Number: