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GKT137831 reduced the increased leukocyte adherence to the vasculature
KG1 and NB4 cells with IC50 of 50 nM
InChi: InChI=1S/C14H15N5S/c1-19(2)14(20)18-17-13(11-7-3-5-9-15-11)12-8-4-6-10-16-12/h3-10H
Chemical Name: N'-(5-chloropyridin-2-yl)-N-[(1S
BAY 61-3606 dihydrochloride ntel GKT137831 reduced the increased leukocyteBAY 61 3606 is a potent (Ki = 7. 5 nM) and selective inhibitor of Syk kinase. BAY 61 3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61 3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8. 1 nM). B cell receptor
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