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Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer
BAF312 is currently in clinical trials to treat multiple sclerosis
At tolerated doses
Hammitzsch A
NI-57 - BRPF Bromodomain Inhibitor. CAS# 1883548-89-7 Catalog No.:M60279-10S Hedgehog signaling antagonist promotes regressionNI 57, CAS No. 1883548 89 7, is a potent and selective inhibitor of the bromodomain of the BRPFs. It binds to BRPF1B with a KD of 31 nM (ITC), to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC). NI 57 is very selective against other non Class IV bromodomains, including the BETs, has minimum 32 fold selectivity against BRD9. It shows accelerated FRAP recovery at 1 M in the BRPF2 FRAP assay preventing binding of full length BRPF2 to
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