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LD50: Mice 2356
38(6):1260-5
which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor
Epub 2012 Apr 6
Pentostatin Size:Solid 2 mg LD50: Mice 2356Pentostatin is classified as a purine analog, which is a type of antimetabolite. It mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, interfering with the cell's ability to process DNA. Cancer cells generally divide more often than healthy cells; DNA is highly involved in cell division (mitosis) and drugs which target DNA related processes are therefore more toxic to cancer cells than healthy cells. Pentostatin is used
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