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Incensole acetate reduces Aβ25–35-triggered apoptosis in hOBNSCs
and 1127 nM for p110α
Smiles: CN(C)[C@H]1CN(C[C@@H]1C1=CC=C(C=C1)N1CCN(CC1)S(C)(=O)=O)C1CCC2=CC=CC(F)=C21
44)45)13-23(35)29(19)33(31)41)18-4-6-26(16(2)8-18)38-40-32-28(58(52
ONO-4059 (analog) or modulator-1 Incensole acetate reduces Aβ25–35-triggered apoptosisONO 4059 analog is the analog of ONO 4059, ONO 4059 is a highly potent and selective Btk inhibitor. IC50 value: sub nM range Target: Btkin vitro: ONO 4059 is a selective, once daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B cells. ONO 4059 shows a favourable safety profile along with promising efficacy in this difficult to treat patient population. in vivo: ONO 4059 has demonstrated
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