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PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid Prevalence of hepatitis C virus

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Description

Prevalence of hepatitis C virus variants resistant to NS3 protease inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with genotype 1b

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

Chemical Name: 5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide

CAS Number: 1675201-83-8

PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid Prevalence of hepatitis C virusPP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.

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