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Smiles: CC(=O)C1C=CC(=CC=1)NC1=C(Cl)C(=O)C2=CC=CC=C2C1=O
14(2):163-170
Formula: C43H63ClFN5O13S
18-11-/t19-
L-778123 hydrochloride Size:Contact [email protected] for quotation Smiles: CC(=O)C1C=CC(=CC=1)NC1=C(Cl)C(=O)C2=CC=CC=C2C1=OL 778123 hydrochloride is an inhibitor of FPTase and GGPTase I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. IC50 value: 2 nM Target: FPTasein vitro: L 778123 can completely inhibit Ki Ras prenylation. L 778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti cancer agent. in vivo: In the dog model, L 778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of
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