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It has at least 60-fold selectivity as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members such as KDM3A
5 was used at 25 nM to induce Hh pathway activation in the reporter gene assay
Screening: Your brain on drugs
InChiKey: PMATZTZNYRCHOR-CGLBZJNRSA-N
GSK2879552 dihydrochloride - LSD1 Inhibitor. CAS# 1902123-72-1 size:10mg solid It has at least 60-foldGSK2879552 dihydrochloride, CAS No. 1902123 72 1, is a highly potent, selective and orally bioavailable irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It is highly selective over related enzymes such as MAO A B. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to GSK2879552s inhibition. It increases H3K4 methylation selectively at genomic regions
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