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Lindgren AE
Epub 2007 Feb 28
Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors
PubMed PMID: 25547937
CK-636 - CAS# 442632-72-6 434 Lindgren AECK 636, CAS No. 442632 72 6, is a Arp2 3 complex inhibitor. CK 636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK 636 inserts into the hydrophobic core of Arp3 and alters its conformation. Polymerization of actin filaments directed by the actin related protein (Arp)2 3 complex supports many types of cellular movements. CK 636 may be a powerful tool compound for studying the Arp2 3
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