TMC647055 Choline salt 5041 sodium 4-dihydro-2H-quinolin-1-yl]-N-methyl-1-tetrahydropyran-4-yl-6

4-dihydro-2H-quinolin-1-yl]-N-methyl-1-tetrahydropyran-4-yl-6

COC1C=CC(=CC=1)C1SC2=CC(O)=CC=C2C=1OC1C=CC(=CC=1)OCCN1CCCCC1

5 mg/kg for 4 weeks displays potent antitumor activity in the N-methyl-N-nitrosourea carcinogen-induced rat mammary carcinoma model

InChi: InChI=1S/C25H22FNO3/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-19-13-18(28)14-23(29)30-19/h1-4

TMC647055 Choline salt 5041 sodium 4-dihydro-2H-quinolin-1-yl]-N-methyl-1-tetrahydropyran-4-yl-6TMC647055 choline salt is a cell permeating, selective HCV NS5B inhibitor, eliciting a mean IC50 of 34 nM, as assessed in the RdRp primer dependent transcription assay. IC50 value: 34 nM Target: HCV NS5Bin vitro: TMC647055 is a novel and potent nonnucleoside inhibitor of the HCV NS5B RNA dependent RNA polymerase. TMC647055 shows high selectivity for HCV when evaluated with a broad panel of human DNA and RNA viruses. TMC647055 shows median EC50 changes