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Formula: C12H9Cl2NO4
It has excellent in vitro ADME properties
A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury
79 µM respectively
CUDC-907 - PI3K/HDAC dual inhibitor. CAS# 1339928-25-4 size:2mg solid Formula: C12H9Cl2NO4CUDC 907, CAS No. 1339928 25 4, is a potent inhibitor of class I PI3K kinases with an IC50 of 19 nM, 54 nM, 311 nM and 39 nM for PI3K, PI3K, PI3K and PI3K. It also potently inhibits HDAC1, HDAC2, HDAC3, HDAC6, HDAC10 and HDAC11 with IC50 of 1. 7 nM, 5 nM, 1. 8 nM, 27 nM, 2. 8 nM and 5. 4 nM respectively. Through its simultaneous HDAC inhibitory activity, CUDC 907 durably inhibits the PI3K AKT mTOR pathway and compensatory signaling molecules such as
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