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InChi: InChI=1S/C16H14BrN3O2
TDZD8 (10 μM) treatment also triggers a drastic autophagy response and AMPK activation in PC-3 cells
Mice treated orally with 10 mg CZC24832 per kg body weight twice per day show a substantial decrease of bone and cartilage destruction (53% reduction by histopathological analysis) as well as of overall clinical parameters (38% reduction)
SF-1670 also elevates Akt phosphorylation in murine cells
U 0126(ZZ) ogenic acid InChi: InChI=1S/C16H14BrN3O2U0126 is a potent and selective non competitive inhibitor of MAP kinase. Inhibits MEK 1 and MEK 2 (IC50 values of 0. 07 and 0. 06 M respectively). Product information CAS Number: 218601 62 8 Molecular Weight: 380. 49 Formula: C18H16N6S2 Synonym: U0126 U 0126 Related CAS Number: 1173097 76 1 (U0126 EtOH) Chemical Name: (2Z, 3Z) 2, 3 bis(amino((2 aminophenyl)thio)methylene)succinonitrile Smiles: NC1=CC=CC=C1S C( N)=C(\C#N) C( C#N)=C(\N) SC1=CC=CC=C1N